Gene Expreession and Function of Progesterone Receptor Isoforms
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چکیده
منابع مشابه
Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling
Major roadblocks to developing effective progesterone receptor (PR)-targeted therapies in breast cancer include the lack of highly-specific PR modulators, a poor understanding of the pro- or anti-tumorigenic networks for PR isoforms and ligands, and an incomplete understanding of the cross talk between PR and estrogen receptor (ER) signaling. Through genomic analyses of xenografts treated with ...
متن کاملRole of nuclear progesterone receptor isoforms in uterine pathophysiology.
BACKGROUND Progesterone is a key hormonal regulator of the female reproductive system. It plays a major role to prepare the uterus for implantation and in the establishment and maintenance of pregnancy. Actions of progesterone on the uterine tissues (endometrium, myometrium and cervix) are mediated by the combined effects of two progesterone receptor (PR) isoforms, designated PR-A and PR-B. Bot...
متن کاملEffects of mating on progesterone receptor isoforms in rat hypothalamus.
In rodents, the display of sexual behavior during proestrus-estrus transition depends on the effect of estradiol and progesterone. Progesterone exerts its effects through intracellular receptor (PR) of which two isoforms (PR-A and PR-B) are found, with different regulation and function. In this study the effects of mating on the expression pattern of PR isoforms in the hypothalamus were investi...
متن کاملAssociation of Alu Insertion Polymorphism in Progesterone Receptor Gene with Risk of Multiple Sclerosis
Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...
متن کاملFrequency of Polymorphism Alu Insertion in Progesterone Receptor Gene in Endometriosis
Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1994
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.70.6_537